Imaging in the repair of peripheral nerve injury

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Peripheral nerve injury and repair.

Peripheral nerve injuries are common, and there is no easily available formula for successful treatment. Incomplete injuries are most frequent. Seddon classified nerve injuries into three categories: neurapraxia, axonotmesis, and neurotmesis. After complete axonal transection, the neuron undergoes a number of degenerative processes, followed by attempts at regeneration. A distal growth cone see...

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The Effect of Ultrasound on Acceleration of Peripheral Nerve Injury

Background: Many people suffer from nerve injury. The time consuming nature of the treatments makes the condition worse. Therefore, finding a way to accelerate the process of nerve repair is very important.Objective: To determine the effect of ultrasound on the acceleration of crushed peripheral nerve regeneration.Methods: The experimental model included crushed rat’s sciatic nerve. 40 rats w...

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Morphological Identification of Cell Death in Dorsal Root Ganglion Neurons Following Peripheral Nerve injury and repair in adult rat

Background: Axotomy causes sensory neuronal loss. Reconnection of proximal and distal nerve ends by surgical repair improves neuronal survival. It is important to know the morphology of primary sensory neurons after the surgical repair of their peripheral processes. Methods: Animals (male Wistar rats) were exposed to models of sciatic nerve transection, direct epineurial suture repair of sciati...

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High-resolution live imaging reveals axon-glia interactions during peripheral nerve injury and repair in zebrafish

Neural damage is a devastating outcome of physical trauma. The glia are one of the main effectors of neuronal repair in the nervous system, but the dynamic interactions between peripheral neurons and Schwann cells during injury and regeneration remain incompletely characterized. Here, we combine laser microsurgery, genetic analysis, high-resolution intravital imaging and lattice light-sheet mic...

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Advance of Peripheral Nerve Injury Repair and Reconstruction

Peripheral nerve injury is a common clinical problem because the dysfunction of distal limb seriously affects patients’ quality of life, and it results in a huge social and economic burden.[1] Repair of peripheral nerve injury is a very complex pathological process. Due to slow nerve regeneration, Wallerian degeneration of nerve stump, tissue adhesion, atrophy of muscles and motor end plates an...

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ژورنال

عنوان ژورنال: Nanomedicine

سال: 2019

ISSN: 1743-5889,1748-6963

DOI: 10.2217/nnm-2019-0115